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DRY EYE SYNDROME

 

References

1. http://www.google.com/search?q=three+layer+tear+film
2. http://www.google.com/search?q=sebaceous+glands
3. http://www.google.com/search?q=lacrimal+glands
4. http://www.google.com/search?q=meibomian+glands
5. http://www.google.com/search?q=mucin+layer
6. http://www.google.com/search?q=Neural+Arc+dry+eyes
7. http://www.google.com/search?q=corneal+sensory+nerves
8. http://www.ophthalmologytimes.com/...?id=52547
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10. http://www.naturalypure.com/BrainFood.htm
11. http://www.novartisophthalmics.com/consumers/dryeye.shtml
12. http://www.ncbi.nlm.nih.gov/...12888052&dopt=Abstract
13. http://dailynewspaper.subportal.com/.../504681.html
14. http://www.tedmontgomery.com/the_eye/cornea.html
15. http://www.eri.harvard.edu/htmlfiles/pubs/sg1299.dryeyeimg.html
16. http://www.eri.harvard.edu/htmlfiles/pubs/sg1299.dryeye.html
17. http://www.theschepens.org/
18. http://www.theschepens.org/...sannualreport.pdf
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21. http://www.escrs.org/eurotimes/July2003/outlook.asp
22. Ann N Y Acad Sci. 2002 Jun;966:211-22. Androgen deficiency, Meibomian gland dysfunction, and evaporative dry eye. http://www.ncbi.nlm.nih.gov/...Abstract
23. http://www.peoplelivingwithcancer.org/...002751,00.asp
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26. http://www.andrologyaustralia.org/.../testosterone.htm
27. http://www.testosterones.com/androgenreplacement.htm
28. http://www.4-men.org/testosterone2.html
29. http://www.bodybuilding.com/store/tl/zma.html
30. http://www.bodybuilding.com/store/testkits.html
31. http://vioxx.online-dot.com/VIOX/vioxx.html
32. http://www.endocrineweb.com/TFT.html
33. http://www.fda.gov/cder/consumerinfo/druginfo/vioxx.htm
34. http://www.bremercommunications.com/Computer_Eyes.htm
35. http://lds.about.com/library/weekly/aa121202b.htm
36. http://bjo.bmjjournals.com/cgi/content/short/84/1/76
37. http://www.emedicine.com/oph/byname/dry-eye-syndrome.htm
38. http://www.prodigy.nhs.uk...eye%20syndrome
39. http://www.calvin.edu/news/releases/2000_01/ubels.htm
40. http://www.mindfully.org.../Baby-Bottle-Danger31mar03.htm
41. http://ehp.niehs.nih.gov/docs/2003/5440/abstract.html
42. http://www.ourstolenfuture.org/NewSci...wetherill.htm

43. Wetherill, YB, CE Petre, KR Monk, A Puga, and KE Knudsen. 2002. The Xenoestrogen Bisphenol A Induces Inappropriate Androgen Receptor Activation and Mitogenesis in Prostatic Adenocarcinoma Cells . Molecular Cancer Therapeutics 1: 515–524 .
44. http://www.newsomeye.com/dryeyes.htm
45. http://eces.org/articles/000116.php
46. http://www.checnet.org/...-detail.asp?Main_ID=275
47. http://www.sdsc.edu/Education/Elemnet/andy/plastics.html
48. http://www.ehs.lilly.com/...ointment.html
49. http://website.lineone.net/~mwarhurst/bisphenol.html

50. Exp Eye Res. 1999 Jul;69(1):1-7. Functional MRI of brain activation by eye blinking. Tsubota K, Kwong KK, Lee TY, Nakamura J, Cheng HM.

51. http://www.biology.duke.edu/jackson/treephys00.html
52. http://www.eyemdlink.com/Condition.asp?ConditionID=55
53. http://www.ada.org/prof/prac/issues/statements/seal-est.html
54. http://en.wikipedia.org/wiki/Isoprene
55. http://www.wissensdrang.com/auf1isop.htm
56. http://www.augen.de/American/Patienteninfo/trockenes_auge.html

57. Surv Ophthalmol. 1977 Sep-Oct;22(2):69-87. Tear physiology and dry eyes. The conditions of tear film formation and stability are governed by the surface chemical characteristics of the tear film system and by the proper functioning of the lacrimal apparatus. The tear film has to remain continuous between blinks in order to fulfill it function. The presence of an abnormal tear film results in dry eye states that can be detrimental to vision. ...

58. Cornea. 1999 Jul;18(4):403-7. Corneal thickness is reduced in dry eye. The average thickness of nine sites in the central and midperipheral cornea was significantly decreased in dry eyes compared with that of normal eyes. The superior cornea was found to be the thickest area in both groups, measuring 0.629 +/- 0.030 mm in normal eyes and 0.589 +/- 0.031 mm in dry eyes. The center of the cornea was noted to be the thinnest in both groups, measuring 0.571 +/- 0.028 mm and 0.534 +/- 0.034 mm in normal and dry eyes, respectively. ../ The mean astigmatism was 0.99 +/- 0.43 diopter (D) in normal corneas and 1.42 +/- 0.92 D in dry eyes (p = 0.015). ...

59. Arthritis Rheum. 1992 Dec;35(12):1492-501. Association of dry eyes and dry mouth with anti-Ro/SS-A and anti-La/SS-B autoantibodies in normal adults. The association between self-reported symptoms of dry eyes or dry mouth and anti-Ro and anti-La, found in more than one-third of mature adults in this study, suggests that the immune abnormalities and exocrine gland dysfunction found in Sjogren's syndrome affect a substantial proportion of the general population.

60. Current Allergy and Asthma Reports 2004, 4 :314-319. Dry Eye: Diagnosis and Current Treatment Strategies. One in four patients attending ophthalmic clinics report symptoms of dry eye, making it one of the most common complaints seen by ophthalmologists. Aqueous-layer deficiency is the most common form of dry eye and is frequently caused by decreased secretion of tears by the lacrimal glands. Evaporative dry eye is often secondary to meibomian gland disease and results in a defective lipid layer. ... Newer forms of therapy ... include the use of topical cyclosporin A, autologous serum, and sodium hyaluronate drops, which suppress underlying inflammation, provide growth factors, and prevent the onset of squamous metaplasia in ocular surface epithelium.

61. http://www.sjogrensyndrom.se/100-site/spdfs/S24.pdf Bion Tears is the only tear substitute on the market with a stable content of sodium bicarbonate needed to help heal the corneal epithelium.

62. http://www.iovs.org/cgi/content/full/44/2/533 "Obstructive MGD is the major cause of lipid tear deficiency and evaporative dry eye and has recently attracted attention as a cause of ocular discomfort ... Obstructive MGD decreases the lipid supply, which in turn leads to decreased tear stability, loss of lubrication, and damage to the ocular surface epithelium, thus producing symptoms "

63. Adv Exp Med Biol. 1998;438:281-95. The meibomian glands and tear film lipids. Structure, function, and control.

64. Ophthalmology. 2000 Jan;107(1):180-4. Immunohistochemical evidence for estrogen receptors in meibomian glands. " Estrogen receptors are present in the meibomian glands of the upper eyelid. Unlike sebaceous glands elsewhere on the skin, the meibomian glands lack androgen receptors. Estrogen receptors may play a role in modulation of the lipid layer of the tear film, and their activity may be linked to meibomian gland dysfunction and dry eye syndrome. "

65. The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 12 4874-4882. Effect of Androgen Deficiency on the Human Meibomian Gland and Ocular Surface. "... the use of antiandrogen pharmaceuticals was associated with significant changes in the relative amounts of lipids in meibomian gland secretions. Our findings indicate that chronic androgen deficiency is associated with meibomian gland dysfunction and dry eye. "

66. Wickham LA, Gao J, Toda I, Rocha EM, Ono M, Sullivan DA. 2000 Identification of androgen, estrogen and progesterone receptor mRNAs in the eye. Acta Ophthalmol. 78:146–153

67. Rocha EM, Wickham LA, Silveira LA, et al. 2000 Identification of androgen receptor protein and 5 {alpha}-reductase mRNA in human ocular tissues. Br J Ophthalmol. 84:76–84. [Abstract/ Free Full Text]

68. Yankelovich and Partners Survey
69. Dry eye and closed eye tears. Cornea. 2000 May;19(3 Suppl):S44-8. Related Articles, Links. Fukuda M, Wang HF.
70. Membrane Array Characterization of 80 Chemokines, Cytokines, and Growth Factors in Open- and Closed-Eye Tears: Angiogenin and Other Defense System Constituents. (Investigative Ophthalmology and Visual Science. 2005;46:1228-1238.)
71. Diurnal tear cycle: evidence for a nocturnal inflammatory constitutive tear fluid. Investigative Ophthalmology & Visual Science, Vol 33, 626-640
72. Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3, Advances in Experimental Medicine and Biology, Volume 506, W3 AD74 v.506 pt. A (2002) pg. 6

Yankelovich and Partners Survey
 

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